Viruses: Origin, Classification and Role in the Environment
The word "virus" comes from Latin and means literally "poison." Viruses are usually associated with negative effects. Without viruses, though, the Earth would be a different place, maybe even a planet without life. Viruses are the most abundant form of life on Earth, with a population now estimated at 1030 - a billion billion trillion. Most of the diversity of life's genetic information may reside in their genome. Within the human gut alone there are about a thousand species of viruses.5 Viruses are the most abundant biological entity in both freshwater and seawater. More than 1 million viruses are present in a teaspoon of water. Most of these viruses are known as bacteriophages (viruses that infect bacteria). For each bacterium in the water there 15 to 25 virus particles.
a cause of fatal hemorrhagic fever
Courtesy of CDC
Viruses are the smallest and simplest infectious agents identified to date. They are little more than a piece of genetic material protected by a protein coat. Viruses are about 500 smaller than a bacteria and can only be seen with an electron microscope which can magnify 100,000 times and higher. Many of the small viruses behave like chemicals and can be crystallized.
The Origin of Viruses
Nobody knows for sure where viruses came from. Some scientists speculate that these particles of genetic material broke away from genes in animals and plants and found a way to exist as parasites.
The DNA contains "jumping genes," snippets of DNA that can detach from one part of a DNA strand and reattach at another site. Some jumping genes contain instructions for making useful proteins. It is believed that some of these gene segments found a way to leave their "home" cells and to exist parasitically as viruses. In the early stages of life on Earth, these genes may have moved between organisms, increasing genetic diversity and aiding evolution. Now they exist independently, but they need hosts to reproduce.3
A 3D graphical representation of a generic influenza virion's structure. A portion of the virion's outer protein coat has been cut away, which reveals the virus'contents.
Courtesy of CDC
Viruses force their hosting cells to reproduce their genes for them. Genes consist of strands of deoxyribonucleic acid, also known as DNA. Cells are selective about which chemicals they let in and which they keep out. Special receptors on the cell's surface permit only of those chemicals the cell needs. After attaching to the receptor, the virus either enters the cell or injects its genetic material into it. The virus uses the cell's proteins and enzymes to replicate viral genes and build new viral particles. These new viruses leave the host cell and invade other cells.
Classification of Viruses
Historically, viruses were first classified by the diseases they caused, but this led to much confusion because a single virus can be responsible for several diseases. In addition, several unrelated viruses can produce similar diseases. For example, viruses that cause hepatitis (liver swelling and resulting jaundice) were called hepatitis viruses. Yet it is now known that these viruses have very different structure. Classification according to appearance under an electron microscope was more successful. However, this also created confusion because different virus species may look alike. Currently, viruses are classified according to the type of nucleic acid in their genes (double-stranded DNA, single-stranded DNA, double-stranded RNA, and single-stranded RNA), type of replication and the structure of the virus particle. These features are usually maintained during virus evolution.2
The International Committee on Taxonomy of Viruses (ICTV) is attempting to devise a uniform system for the classification and naming of all viruses. Viruses are classified into species on the basis of a close relationship which are then grouped into a genus; genera are grouped into families. The ICTV has recognized more than 5450 viruses as species.4
Viruses Versus Bacteria
Bacteria are the blue print for cells which make up all other animals and plants. They are the smallest microscopic organisms that can survive without help from any other living thing, most of them being just single cells which live in the natural environment. Everyday they are busy breaking down dead plants and animals into their component parts ready for use. The gases released make up our atmosphere, and simple molecules are rebuilt into new plants and animals. Unlike bacteria, viruses can do absolutely nothing on their own. They are not cells but particles and they have no source of energy. They invade living things, commandeer their cells, and turn them into factories for virus reproduction.1
Human Immunodeficiency Virus
A member of the genus Lentivirus, HIV is separated into two serotypes, HIV-1 and HIV-2, and is the cause for the disease known as acquired immunodeficiency syndrome, or AIDS.
Courtesy of CDC
Viruses and Viroids
One of the characteristics that viruses and viroids have in common is that
they both produce diseases in their hosts. Viruses and viroids also have several
important structural and functional differences.
Viruses are submicroscopic spherical, rod-shaped, or filamentous entities
that consist of only one type of nucleic acid (DNA or RNA). The nucleic acid is
surrounded by a coat consisting of one or more kinds of protein molecules.
Viruses infect and multiply inside the cells of different types of
Viroids are the smallest infectious agents that multiply autonomously in
plant cells; they consist of only small, circular RNA molecules that are too
small to code for even one protein and therefore lack a protein coat and are
"naked." About 25 viroids have been identified.
Viruses often have methylated ribonucleotides in their genomes, whereas
viroid RNA lacks modified bases. All virus RNAs are subject to host cell's
enzymatic degradation; viroid genomes are resistant.
Because viroids do not possess any molecules or structures to facilitate
their entry into a host, they depend on wounding of a plant, for example, by an insect, to gain entry.
Viruses That Cause Tumors
As of now, viruses have been implicated in the formation of at least eight
- The Epstein-Barr virus (EBV) is the cause of two cancers, Burkitt's lymphoma (a malignant tumor of the jaw and abdomen in children of central and western Africa) and nasopharyngeal carcinoma.
- Hepatitis B virus causes hepatocellular carcinoma (liver cancer).
- Hepatitis C virus causes cirrhosis of the liver which can lead to liver
- Human herpes virus 8 is associated with Kaposi sarcoma.
- Some strains of human papillomaviruses have been linked to cervical cancer.
- Human T-cell lymphotropic virus I (HTLV-1) causes adult T-cell leukemia.
- Human T-cell lymphotropic virus II (HTLV-2) causes hairy-cell leukemia.
With the possible exception of HTLV-1, little is known how the viruses
associated with human cancers actually aid in cancer development.
Last updated: May 8, 2012