Feline eosinophilic granulomas are well-defined reddish to yellow-colored, raised skin areas that may appear anywhere on the body or in the mouth of affected cats. The abnormal areas may form firm bumps in the skin. Most linear granulomas are found on the surface of the hindlegs. Another common site is the chin. They are often found incidentally during physical examination, since eosinophilic granulomas are rarely associated with discomfort, and they often seem to wax and wane in size even if untreated.
As with other skin conditions of cats, treatment for eosinophilic granuloma complex (EGC) is most successful when the cause of the problem is found and removed. Since all of the skin abnormalities in this group have been associated with allergy, attempts should be made to rule out fleas and other skin parasites, foods, and inhaled allergens as triggers for this skin reaction or repeated problems will be likely. Keep your cat clean and practice good flea control. If food allergy is suspected, you'll need to feed a restricted diet for at least 4 weeks to discern any positive response.
Most cases of EGC will not respond to simple home care, since the skin abnormalities represent a reaction to long-standing stimulation of the immune system. Your vet may prescribe corticosteroid drugs (prednisone), fatty acid supplements, and/or antibiotics to treat certain cases. For some difficult cases, immunomodulating drugs other than corticosteroids are used, but most veterinarians prefer to avoid them due to their potential for serious side effects. To this end most veterinarians will perform diagnostic tests such as complete blood counts (CBCs), skin biopsies, and skin testing in addtion to physical examination.