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Multiple Hereditary Lipomatosis

Multiple hereditary lipomatosis is a hereditary skin and connective tissue disease characterized by the growth of benign masses of fat tissue (lipomas) symmetrically deposited around the neck, shoulders, and other sites of the body. The presence of multiple lipomas is known as lipomatosis which is thought to be caused by a defect in fat metabolism. Up to several hundred of lipomas can be present in lipomatosis. Lipomas most often develop under skin, but sometimes can penetrate muscles. The tumors can vary from a size of a pea to that of a soccer ball and are composed of fat enclosed in a thick, fibrous capsule. The adipose tissue of the tumor is often indistinguishable from normal fat. On palpation, they feel smooth and compressible. Canine lipomatosis has been described in Dachshunds. Dogs with this condition have progressively enlarging, pendulous skin folds involving both sides of the neck and trunk. The skin is soft, ulcerated, with partial hair loss.

Besides surgical removal of lipomas, novel treatment of lipomatous tumors use antibodies derived from adipose tissue of a mammal donor. The methods are effective against both benign and malignant lipomatous tumors. The antibodies are used to decrease the size of lipomatous tumors, prevent the regrowth of removed tumors, and inhibit the proliferation of lipomatous cells.3

References

  1. Thomas J Zuber and E. J Mayeaux. Atlas of Primary Care Procedures
  2. Montgomery/AAro. Clinical Pathology of Soft-Tissue Tumors.
  3. United States Patent Application 20070048323. Kind Code A1. Rubin; J. Peter March 1, 2007. Antibody treatment of lipomatous tumors
  4. Peter J. Ihrke, Emily J. Walder, Verena K. Affolter, Thelma Lee. Skin Diseases of the Dog and Cat.



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