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Optic Nerve Hypoplasia
Two important congenital disorders that affect the optic nerve and optic disk in dogs are coloboma (localized absence of optic nerve tissue) and optic nerve hypoplasia (underdevelopment of the optic nerve). The nerve may also be impaired by inflammation (optic neuritis), swelling (papilledema), or shrinkage (optic atrophy).
Optic nerve hypoplasia is a relatively rare condition, and may be uni- (one eye is affected) or bilateral (both eyes are affected). In this condition the optic nerve appears extremely small because of its underdevelopment. Either eye can be affected by this congenital abnormality, and affected eyes frequently are blind. Because blindness in one eye is compensated by sight in the other, hypoplasia affecting only one eye often will go undetected.
Affected eyes have reduced numbers of retinal ganglion cell axons. Resting pupil size may be normal (regulated from the opposite eye)
or dilated (with bilateral optic nerve hypoplasia). Examination reveals a small or barely detectable optic nerve. The retinal blood vessels are present; but the number of arterioles and veins may be reduced. It is best to withhold affected dogs from breeding programs, since the condition is known to be inherited in certain breeds (Miniature Poodle), while in others it is associted with other inherited eye disorders and a broad range of disorders of the central nervous system. There is no effective therapy for this condition.
Breeds affected by the optic nerve hypoplasia include Dachshund,
Great Pyrenees, Irish Setter, Miniature schnauzer, Norfolk terrier,
Toy Poodle, Miniature Poodle, Standard Poodle, and Saint Bernard
Dog breeds that are predisposed to optic nerve hypoplasia
References:
1. UC Davis Book of Dogs : The Complete Medical Reference Guide for Dogs and Puppies, Mordecai Siegal
2. Color Atlas of Veterinary Ophthalmology, Kirk N. Gelatt
Go Pets America recommends seeking the advice of your local veterinarian for the most appropriate vaccination program and for the diagnosis and treatment of your pet's health problems. For vaccination requirements please contact your state and local licensing authorities.
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