Polyneuropathy

Polyneuropathy is the malfunction of many peripheral nerves throughout the body. Polyneuropathy may be acute (beginning suddenly) or chronic (developing gradually, often over months or years). Polyneuropathy means there are several nerves involved. Polyneuropathy usually affects both sides of the body equally. The cause of chronic inflammatory polyneuropathy is an abnormal immune response . The specific processes and triggering factors vary and, in many cases, are unknown.

This neurological disorder characterized by progressive weakness in the limbs, exercise intolerance, high-steppage pelvic-limb gait, a loss or change in the pitch of the bark, and difficulty breathing. The disorder, which is sometimes called chronic relapsing polyneuropathy, is caused by damage to the myelin sheath (the fatty covering that wraps around and protects nerve fibers) of the peripheral nerves. It often presents with weakness of the limbs, loss of muscle reflexes (areflexia), and fatigue. The mean age of onset of clinical signs in all affected dogs is 10 to 18 months.

Cases of hereditary have been observed in Leonbergers. Neurological examination reveals marked atrophy of the limb muscles, depressed spinal and cranial nerve reflexes, and weak or absent movement of the throat and voice box muscles.

The distal sensorimotor polyneuropathy in Rottweilers is characterized by distal muscle denervation, but the cause is unknown. It affects young adult Rottweilers. Although signs may appear acutely, the course tends to be gradually progressive (up to 12 months or longer in some dogs) and may be relapsing.[2] The symptoms include weakness of all four legs and decreased reflexes. The disease is gradually progressive. Treatment is possible with corticosteroids, but the prognosis is poor. The condition is believed to have similariries to hereditary motor and sensory neuropathy (HMSN) type II in humans.[2]

Generalized polyneuropathy may present as laryngeal paralysis (several cases of Dalmatians and Bouvier des Flandres). Two forms of this generalized polyneuropathy may exist: an early form, as seen in young dogs with congenital or hereditary disease, and a delayed-onset form that is usually found in older dogs with so-called idiopathic laryngeal paralysis, some of which may have hypothyroidism.[3]

The cause of polyneuropathy in Alaskan Malamutes is undetermined. Dogs may not have evidence of metabolic, toxic, or autoimmune disease. The occurrence of this condition in Alaskan Malamutes strongly suggests a genetic disease. Although pedigree data are incomplete, an autosomal recessive mode of inheritance is suggested.

Over the past decade, several breed-related peripheral neuropathies have been reported in dogs, including laryngeal paralysis-polyneuropathy complex in young Dalmatian Dogs; laryngeal paralysis in young Bouvier des Flandres and Siberian Husky Dogs; congenital hypomyelinating polyneuropathy in Golden Retriever puppies; spinal muscular atrophy in young Rottweilers, Brittany Spaniels, English Pointers, Swedish Laplands, German Shepherd Dogs and Cairn Terriers; hypertrophic neuropathy in young Tibetan Terrier Dogs; giant axonal neuropathy in young adult German Shepherd Dogs; distal sensorimotor polyneuropathy in mature Rottweiler Dogs; sensory neuropathies in young Boxer, English Pointer, and Dachshund Dogs; globoid leukodystrophy in Cairn and West Highland White Terriers; and fucosidosis in Springer Spaniels.[4]

Treatment of Polyneuropathy

Treatment for CIDP includes corticosteroids such as prednisone, which may be prescribed alone or in combination with immunosuppressant drugs.[1]

Adapted from
1. Polyneuropathy. Merck Manual, Home Edition
2. K. G. Braund, M. Toivio-Kinnucan, J. M. Vallat, J. R. Mehta and D. C. Levesque. Distal sensorimotor polyneuropathy in mature Rottweiler dogs. Veterinary Pathology, Vol 31, Issue 3 316-326, Copyright © 1994 by American College of Veterinary Pathologists
3. Braund KG, Steinberg HS, Shores A, Steiss JE, Mehta JR, Toivio-Kinnucan M, Amling KA. Laryngeal paralysis in immature and mature dogs as one sign of a more diffuse polyneuropathy. Neuromuscular Laboratory, College of Veterinary Medicine, Auburn University, AL 36849-3501.
4. Kyle G. Braund, Andy Shores, Chuck T. Lowrie, H. Steven Steinberg, Michael P. Moore, Rod S. Bagley, and Janet E. Steiss. Idiopathic Polyneuropathy in Alaskan Malamutes