Gopetsamerica.com

Spherocytosis

Hereditary spherocytosis (HS) is a form of hemolytic anemia characterized by an abnormal spherical shape of red blood cells and their increased permeability to sodium ions. Spherocytes are approximately two-thirds the diameter of normal red blood cells. These abnormalities are believed to result from the defects in the peripheral erythrocyte membrane protein spectrin. Because of these multiple defects, sperocytes are easily destroyed leading to hemolytic anemia. Anemia may be mild, moderate, sever, or not present at all. Severe hemolytic anemia requires red blood cell transfusions. Affected animals have enlarged spleen. In the Golden Retriever the disease is inherited. The non-hereditary spherocytosis can be caused by genetic mutations, nutritional deficiencies, and toxins such as onions, acetaminophen, methylene blue, daily intravenous injections of propofol in cats, phenothiazines, and dried red maple leaves.



References

  1. Slappendel RJ, van Zwieten R, van Leeuwen M, Schneijdenberg CT. Hereditary spectrin deficiency in Golden Retriever dogs. J Vet Intern Med. 2005 Mar-Apr;19(2):187-92
  2. Congenital spherocytic anemia (MedlinePlus)
  3. Gailene Holland, DVM; Paula M. Krimer, DVM, DVSc; Bruce E. LeRoy, DVM, PhD; and Kenneth S. Latimer, DVM, PhD. Spherocytosis: A Brief Overview

Disclaimer

Related Conditions

Congenital Afibrinogenemia

Alloimmune Hemolytic Anemia of the Newborn

Congenital Hypoplastic Anemia

Autoimmune Hemolytic Anemia

C3 Deficiency

Canine Idiopathic Thrombocytopenia

Chronic Eosinophilic Leukemia

Cyclic Neutropenia

Elliptocytosis

Hemophagocytic Syndrome

Hemophilia A

Immune Mediated Hemolytic Anemia

Pelger-Huet Anomaly

Platelet Delta-storage Pool Deficiency

Polycythemia

Pyruvate Kinase Deficiency

Pyruvate Dehydrogenase Complex Deficiency

Reduced Glutathione Deficiency

Selective IgA Deficiency

Spherocytosis

Stomatocytosis

Thrombasthenia

Thromboxane Responsiveness of Platelets

Trapped Neutrophil Syndrome

von Willebrand's Disease




HomeDogsCats Birds Fish Horses Reptiles Small Pets Jobs Animals Biology Garden Pics Video Search Contacts

©2015 Go Pets America, Inc. All Rights Reserved.