Wilm's tumor, also called nephroblastoma, is a cancerous tumor of the kidneys that occurs both in animals and humans. It develops in one out of 10,000 children and is treated successfully with surgery and chemotherapy. Nephroblastoma is associated with some congenital defects, such as urinary tract abnormalities and enlargement of one side of the body. The tumor can become large and spread to other tissues.
Nephroblastoma is a rare tumor and is most often found in juvenile dogs. This cancer arises from the embryonic remnants of the immature kidney. The fist sign of Wilm's tumor in dogs is usually a large lump on the belly and a swollen abdomen. Some dogs can have abdominal pain, blood in the urine, or swelling in the legs. In all previous reports of renal nephroblastoma in puppies less than 1 y of age, treatment with surgery alone or with surgery and adjuvant chemotherapy did not prevent progression of disease and death. Long-term survival has been reported with surgical cytoreduction and radiotherapy in dogs with canine spinal cord nephroblastoma.
- Renal nephroblastoma in a 3-month-old golden retriever