Acetazolamide Sodium
This drug inhibits the activity of brain carbonic anhydrase enzyme in the central nervous system, which slows abnormal and excessive discharge from central nervous system neurons. This action also results in a decreased pressure. The efficacy of acetazolamide in epilepsy is in part due to the production of metabolic acidosis; however, direct actions of acetazolamide in the CNS also contribute to its anticonvulsant action. Inhibition of carbonic anhydrase decreases the rate of formation of aqueous humor and consequently reduce intraocular pressure [1].
Acetazolamide Sodium is in a powder form containing acetazolamide sodium USP equivalent to 25 percent acetazolamide activity.
DRUG CLASS
Anticonvulsant, diuretic
Therapeutic Uses
Carbonic anhydrase inhibitors are indicated primarily as adjuncts to other agents in the treatment of open-angle (chronic simple) glaucoma and secondary glaucoma, and to lower intraocular pressure prior to surgery for some types of glaucoma [1].
BRAND NAMES
Acetazolamide is an active ingredient in the following brand name canine drugs:
DOGS
Acetazolamide is used in dogs as an aid in the treatment of mild congestive heart failure and for rapid reduction of intraocular pressure [2].
Toxicity
Numerous animal studies have demonstrated that the toxicity of acetazolamide was very low in the species studied (mouse, dog, rat, monkey) [1].
Source: REF FILE #AD-105
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