Butatron

Butatron is a non-steroidal anti-inflammatory drug. Its main ingredient is phenylbutazone (PBZ), the most commonly used non-steroidal anti-inflammatory drug (NSAID) in equine practice. In dogs and horses, the drug is used for the relief of inflammatory conditions associated with a musculoskeletal system. It has anti-inflammatory, antipyretic, and analgesic activities. Butatron has been used in ankylosing spondylitis, rheumatoid arthritis, reactive arthritis and acute attacks of osteoarthritis of the hips and knees not responsive to other treatments.^1,2,4

Phenylbutazone is banned for use in any animal intended for human consumption because it causes serious and lethal idiosyncratic adverse effects in humans: peptic ulcer, stomatitis, hepatitis, nephritis, aplastic anemia, leukopenia, agranulocytosis and thrombocytopenia. Phenylbutazone-associated fatalities have occurred after the appearance of GI distress, convulsions, metabolic acidosis, hepatic necrosis, and renal failure. Serious symptoms in adults developed after ingestions of 4 to 40 g; a 2 g injestion in a 1 yr old resulted in death. ^{3, 4}

References:
REF FILE 324-DAC