Dexamethasone

Dexamethasone is a potent synthetic analogue of hydro-cortisone that has a long history of use in veterinary medicine for the treatment of a range of metabolic diseases and inflammatory disorders in companion and farm animals. Animal diseases in which dexamethasone is an effective treatment include inflammation, acetonaemia, non-specific skin disease, shock and stress. Its use in animals is primarily therapeutic. It is also used in human medicine for the treatment of a wide range of diseases. This wide range of therapeutic use reflects the broad spectrum of pharmacological actions of the corticosteroid hormones. The corticosteroids have effects on several important biochemical pathways and cellular transport mechanisms including, cellular sodium transport, glycogen synthesis and antiinflammatory responses [3].

DRUG CLASS
Anti-inflammatory (corticosteroid)

Therapeutic Uses
Anti-Inflammatory Agents, Steroidal; Antiemetics; Antineoplastic Agents, Hormonal; Glucocorticoids, Synthetic; Glucocorticoids, Topical.

BRAND NAMES
Dexamethasone is an active ingredient in the following brand name canine drugs:

• Azium
• Tresaderm
• Voren
• Dexamethasone

DOGS
Dexamethasone is used in dogs as an anti-inflammatory agent.

Toxicity
Prolonged therapy may result in suppression of adrenal gland function.

Source: REF FILE #AD-105