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Tylosin

Tylosin is a veterinary antibiotic (antimicrobial agent) also used as prophylactics during surgery or at generally lower levels of administration to promote an animal's ability to withstand pathogenic challenge when under stress.

Primary Uses
It is used by injection or oral administration to treat Mycoplasma and gram-positive bacterial infections in poultry, swine, and other livestock. Tylosin is an FDA approved nutritional feed additive for chicken and swine for food efficiency/growth promotion. It is also used to treat American foulbrood, a devastating disease of immature bees.

BRAND NAMES
Tylosin is an active ingredient in the following brand name drugs:

  • Tylan Injection 200 mg
  • Tylan Injection 50 mg

Use In Dogs In Cats

Tylan is used for treatment of upper respiratory infections such as bronchitis, tracheobronchitis, tracheitis laryngitis, tonsillitis, and pneumonia caused by Staphylococci species, hemolytic Streptococci species, and Pasteurella multocida. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Tylan is used for treatment of upper respiratory infections when caused by Staphylococci species and hemolytic Streptococci species and for feline pneumonitis when caused by tylosin susceptible organisms. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Toxicity

Thirty dogs with superficial pyoderma were treated orally with tylosin at a dose of 20 mg/kg twice daily for three weeks. One dog suffered transient gastritis after the doses of tylosin and subsequently responded to a different antibacterial agent.[3]

Tylosin Injection is indicated for use in the treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Corynebacterium pyogenes ; foot rot (necrotic pododermatitis) and calf diphtheria caused by Fusobacterium necrophorum and metritis caused by Corynebacterium pyogenes in beef cattle and nonlactating dairy cattle.

In swine, Tylosin Injection is indicated for use in the treatment of swine arthritis caused by Mycoplasma hyosynoviae ; swine pneumonia caused by Pasteurella spp.; swine erysipelas caused by Erysipelothrix rhusiopathiae ; acute swine dysentery associated with Treponema hyodysenteriae when followed by appropriate medication in the drinking water and/or feed.

Adapted from:
1. Hazardous Substances Data Bank
2. FDA
3. Harvey RG; Vet Rec 139 (8): 185-7 (1996)

 


 





 


 


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