Histiocytic Ulcerative Colitis

Colitis is inflammation of the colon (large intestine). Histiocytic ulcerative colitis (HUC), also called granulomatous colitis and Boxer colitis, is an inflammatory bowel disease (IBD) that occurs predominantly in the Boxer breed, but is also diagnosed in the French Bulldog, Doberman Pinscher, Mastiff, Alaskan Malamute, and cats.2 It causes inflammation and ulcers in the lining of the large intestine that bleed and produce pus. The disease is similar in many ways to Whipple's disease in humans. The cause of this disease is unknown, although infections have been suspected, including colonization by Escherichia coli.

Histiocytic Ulcerative Colitis

Affected dogs, which are usually less than 2 years of age, pass soft tan feces, which are often mixed with blood, up to 15 times a day. Profuse diarrhea does not occur, and throughout the course of the disease the affected animal maintains normal body temperature and weight. In advanced cases, lymph nodes may be enlarged. Young Boxer dogs with relatively mild signs of HUC may respond moderately well to medical and dietary therapy with fair prognosis. Sulfasalazine and corticosteroid therapy is the treatment of choice for histiocytic ulcerative colitis. High-fiber diets should be avoided.


  1. Adherent and Invasive Escherichia coli Is Associated with Granulomatous Colitis in Boxer Dogs
  2. Matteo Cerquetella, Andrea Spaterna, Fulvio Laus, Beniamino Tesei, Giacomo Rossi, Elisabetta Antonelli, Vincenzo Villanacci, and Gabrio Bassotti. Inflammatory bowel disease in the dog: Differences and similarities with humans.



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