Dysplasia Epiphysealis Hemimelica

Dysplasia epiphysealis hemimelica is a rare developmental non-cancerous disorder affecting the ends of long bones (epiphyses) that most commonly occurs around the knee and ankle bones. The disorder affects most frequently the German Boxer breed and is usually seen in the first year of life as knee or ankle deformity, painful gait and limp, swelling or a mass on one side of a joint, limitation of motion, muscle wasting, and, occasionally, recurrent locking of the joint. The damage is continuously increases in size until skeletal maturity, and, if left untreated, can cause degeneration of the affected joint, especially if this is a weight-bearing joint. The causes of dysplasia epiphysealis hemimelica are unknown, although error in epiphyseal development that affects the limb buds during early fetal life has been suggested.


  1. Vignoli M, Sarli G, Rossi F, Terragni R, Pozzi L. Dysplasia epiphysealis hemimelica in a Boxer puppy

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