Epidermolysis Bullosa

Epidermolysis bullosa (EB) is a group of genetically determined disorders characterized by the blistering of skin and mucous membranes. There are at least sixteen types of hereditary epidermolysis bullosa, of which EB simplex, junctional EB, and dystrophic EB have been described both in man and domestic animals. Several forms of this condition have been reported in the Collie, Shetland Sheepdog, Toy Poodle, German Shorthaired Pointer, Golden Retriever, Akita, and mixed breeds. Blisters may be present at birth, or develop within the first week of life. The most severe blisters are on the feet, mouth, face, and genitals. In many cases the disease is fatal. Dystrophic epidermolysis bullosa of Golden Retrievers is characterized by blisters and erosions in the mouth and esophageal lining, together with nails dystrophy and growth retardation. The skin lesions regress spontaneously, whereas the lining lesions, notably on the cornea, persist, aggravate and spread.


  1. The Merck/Merial Manual for Pet Health (Home edition)
  2. Bull Acad Natl Med. 2005 Jan;189(1):107-19; Characterization of a canine model of dystrophic bullous epidermolysis (DBE). Development of a gene therapy protocol. Magnol JP, Pin D, Palazzi X, Lacour JP, Gache Y, Meneguzzi G.