Spinal cord necrosis, also known as necrotizing myelopathy, is an inflammatory hereditary disease of the spinal cord seen in the Kooiker dog, Great Dane, and Afghan Hound. The disease can be caused by infections, autoimmune diseases or malignant tumors such as leukemia, although in some cases the cause cannot be established. Necrotizing myelopathy can affect both sexes. Clinical signs begin at 3 to 12 months of age and usually include progressive partial paralysis of the hindlimbs due to death of nervous tissue of the spinal cord. Affected dogs and their direct offspring should be excluded from breeding.