Canine hereditary stomatocytosis is a type of congenital hemolytic anemia that is characterised by reduced or absent stomatin, an integral membrane protein found in red blood cell membranes. The affected red blood cells retain increased amount of water. Consequently the amount of hemoglobin decreases, intracellular sodium concentration increases, while glutathione level decreases. The disease has been described in the Alaskan Malamute (with short limb dwarfism and chondrodysplasia), Dutch Patridge Dog, Miniature Schnauzer, and Pomeranian. The dwarfism and anemia in the Alaskan Malamute are believed to be a result of one defective gene.

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The disease in Dutch Patridge Dogs has been termed familial stomatocytosis-hypertrophic gastritis. Affected animals have retarded growth, diarrhea, increased urination, thirst, poor movement coordination and occasional limb paralysis. Progressive deterioration usually leads to euthanasia while the dogs are still young. Most dogs die from complications, such as liver failure, hypertrophic gastritis renal cysts and neurological diseases.


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  2. Bernard F. Feldman, Joseph G. Zinkl, Nemi Chand Jain. Schalm's Veterinary Hematology
  3. Thomas Carlyle Jones, Ronald Duncan Hunt, Norval W. King. Veterinary Pathology

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