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Imidacloprid

Imidacloprid is a relatively new compound with many uses. It is used as an insecticide for skin applications on animals to control adult fleas; for the treatment of heartworm infestations; for termite and grub control and as an insecticide for crop protection.

Imidacloprid acts as an antagonist by binding to postsynaptic nicotinic receptors in the insect central nervous system.

When administered orally, imidacloprid is rapidly absorbed, metabolized primarily in the liver and excreted mainly in the urine. Imidacloprid does not accumulate in the body and has very low toxicity in mammals. 2

In dogs, the combination of moxidectin and imidacloprid is marketed under Advantage Multi™ brand name. This drug is indicated for the prevention of heartworm disease caused by Dirofilaria immitis; and the treatment and control of intestinal roundworms (Toxocara canis and Toxascaris leonina), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and whipworms (Trichuris vulpis); it also kills adult fleas and treats flea infestations (Ctenocephalides felis). 4

In cats, the combination of moxidectin and imidacloprid is marketed under Advantage Multi™ brand name. This drug is indicated for the prevention of heartworm disease caused by Dirofilaria immitis; for the treatment and control of ear mite (Otodectes cynotis) infestations, intestinal roundworms (Toxocara cati), and hookworms (Ancylostoma tubaeforme); it also kills adult fleas and treats flea infestations (Ctenocephalides felis). 3

There is no specific antidote to treatment of overdoses of imidacloprid. If the exposure is dermal, washing the affected animal with soap and water is indicated. If the exposure is oral, vomiting should be induced, and adsorbent or cathartics may be used. 2

References:
REF FILE 324-DAC

 




 


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