Kanamycin Sulfate

Kanamycin sulfate is an aminoglycoside antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Kanamycin sulfate comprises three components: kanamycin A, the major component, and kanamycins B and C, the minor components. This antibiotic is active against many gram-negative and acid-fast bacteria. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. Kanamycin sulfate is used in the treatment of bacterial infections due to kanamycin sensitive organisms in dogs and cats. Intravenous use of kanamycin sulfate in dogs and cats causes abnormally slow heart rate. In cats and guinea pigs kanamycin sulfate may cause damaging effect on the eighth cranial nerve, the organs of hearing or balance. This drug may cause adverse effects on kidneys in dogs and cats.

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