Neonicotinoids are a class of insecticides which act selectively on nicotinic acetylcholine receptors of insects, but not vertebrates. They are used as antiparasitic agents (nitenpyram, imidacloprid).

Neonicotinoids are among the most effective group of insecticides, especially for controlling sucking insects. They represent a class of chemicals, nicotine mimics, in which the biochemical target is the nicotinic acetylcholine receptor of both central and peripheral nervous systems Similar to the original nicotine, the neonicotinoids bind to these recpetors, resulting in excitation and paralysis followed by insect death.

imidacloprid provides protection against re-infestation of fleas for up to one month in dogs and cats and one week on pet rabbits. It is not necessary to treat puppies or kittens of less than 8 weeks of age because treatment of nursing bitches and queens controls flea infestations on both the dam and the litter. Imidacloprid-containing "spot-on" products (Advantage®DUO, Advantage Multi™) rapidly kill fleas and therefore the incidence of flea allergy dermatitis (FAD) is reduced.

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