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    Proliferative Colitis (Inflammatory Bowel Disease)

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    What Is Proliferative Colitis?

    Proliferative colitis (inflammatory bowel disease) is an intestinal disorder of a variety of domestic animals associated with the presence of an intracellular Campylobacter-like organism (ICLO). In ferrets, this is a relatively uncommon disease that affects young male ferrets under 1 year of age. The infection can spread to lymph nodes and liver.

    Aetiology

    This inflammatory bowel disease, sometimes called “fading ferret syndrome”, probably has multiple causes and may have an underlying genetic trigger, particularly considering its progression to neoplasia in many ferrets. Food allergies and the grain carbohydrates used in commercial food formulations may be a problem.

    Signs & Symptoms

    Clinical signs of proliferative colitis include frequent painful defecation, blood in the green stool, weight loss and diarrhea. Diarrhea may persist for over 6 weeks. Affected ferrets are dehydrated, thin, and may have a partial prolapse of the rectum. The rectal area and tail become smeared with scats, and the affected animals cry and moan when straining to defecate. The ferret loses its weight rapidly and can lose half of its weight in 2 weeks if not treated.

    Clinical signs of proliferative colitis are seen in ferrets that are less than 10 months of age. The animals have green to bloody diarrhea that may persist intermittently for over 6 weeks. Affected ferrets have poor appetite, dehydrated, thin, and have a partial rectal prolapse.

    Diagnosis

    Diagnosis is based on clinical signs and biopsy from the colon tissues.

    Treatment

    Supportive care with antimicrobial therapy are typical treatments of proliferative colitis in ferrets. However, antimicrobial therapy may not change the course of the disease if improvements are not observed after 48 hours of drug therapy. Metronidazole or chloramphenicol treatments for 2 weeks have been reported to be effective.

    Prognosis

    This condition is subject to periodic periods of recurrence, often during times of stress. Severe cases develop neurological signs such as poor movement coordination, head tilt, and tremors. If untreated, the condition may be fatal.

    Video Credits: Armando Hasudungan
    Image Credits: The Gut Microbiome And Beyond

    References:

    1. Shayne C. Gad – Animal Models In Toxicology
    2. MU College of Veterinary Medicine, Ferret Diseases
    3. Bernard E. Rollin – The Experimental Animal In Biomedical Research
    4. John Henry Lewington – Ferret Husbandry, Medicine And Surgery

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