Amylin (amlintide, pancreatic amylin, islet amyloid polypeptide, molecular
is a hormone released by the pancreatic ß cells at the same time as insulin in
response to glucose signal. It acts in concert with insulin to coordinate the
glucose level in the blood. Amylin is a small peptide having 37 amino acid
residues. In healthy adults plasma concentrations of amylin range from 4 to 25
pmol/L. The level of amylin depends on feeding status. Low levels are seen in
the fasting individuals while higher levels are seen after consuming a meal.
Amylin also plays a role in the inhibition of gastric acid secretion, gastric
emptying, pancreatic glucagon and digestive enzyme secretion, and meal-ending
satiation. In humans and other species, food intake results in marked increase
in plasma amylin concentration that begins within 5 min. Evidence that amylin
can decrease food intake in animals has raised interest in its potential
therapeutic applications, especially for controlling obesity.