Amylin Hormone

Amylin (amlintide, pancreatic amylin, islet amyloid polypeptide, molecular formula C165H261N51O55S2) is a hormone released by the pancreatic ß cells at the same time as insulin in response to glucose signal. It acts in concert with insulin to coordinate the glucose level in the blood. Amylin is a small peptide having 37 amino acid residues. In healthy adults plasma concentrations of amylin range from 4 to 25 pmol/L. The level of amylin depends on feeding status. Low levels are seen in the fasting individuals while higher levels are seen after consuming a meal.

Amylin also plays a role in the inhibition of gastric acid secretion, gastric emptying, pancreatic glucagon and digestive enzyme secretion, and meal-ending satiation. In humans and other species, food intake results in marked increase in plasma amylin concentration that begins within 5 min. Evidence that amylin can decrease food intake in animals has raised interest in its potential therapeutic applications, especially for controlling obesity.